Monday, February 18, 2013

New study finds 'hidden' cancer cells, personalized care still a challenge | Essentials

New study finds 'hidden' cancer cells, personalized care still a challenge

Beware of Online Cancer Fraud
Beware of Online Cancer Fraud by The U.S. Food and Drug Administration
License (according to Flickr): United States Government Work
Excerpt:

The cancer cells were not behaving the way the textbooks say they should. Some of the cells in colonies that were started with colorectal tumor cells were propagating like mad; others were hardly multiplying. Some were dropping dead from chemotherapy and others were no more slowed by the drug than is a tsunami by a tissue. Yet the cells in each "clone" all had identical genomes, supposedly the all-powerful determinant of how cancer cells behave. That finding, published online Thursday in Science, could explain why almost none of the new generation of "personalized" cancer drugs is a true cure, and suggests that drugs based on genetics alone will never achieve that holy grail.

People:

John Dick

Overall Sentiment: -0.0126295

Relevance: 0.639822

SentimentQuote
0.0163652"I thought we'd be able to look at the genetics that let some cells propagate, or not be susceptible to chemotherapy, but lo and behold there was no genetic difference," said Dick.
-0.156582"I thought we'd be able to look at the genetics that let some cells propagate, or not be susceptible to chemotherapy, but lo and behold there was no genetic difference," said Dick. "That goes against a main dogma of the cancer enterprise: that if a tumor comes back after treatment it's because some cells acquired mutations that made them resistant."
-0.0736102he said, "but what our data are saying is, there are other biological properties that matter. Gene sequencing of tumors is definitely not the whole story when it comes to identifying which therapies will work."
Sentiment Stats:
  • Number of Quotes: 3
  • Aggregate Sentiment: -0.213827
  • Mean: -0.071275666666667
  • Standard Deviation: 0

Dick

Overall Sentiment: 0

Relevance: 0.306545

SentimentQuote
0"Our findings raise questions about the resources put into sequence, sequence, sequence," said Dick.
Sentiment Stats:
  • Number of Quotes: 1
  • Aggregate Sentiment: 0
  • Mean: 0
  • Standard Deviation: 1.4142135623731

Dr. Charis Eng

Overall Sentiment: 0.0637343

Relevance: 0.254224

Dr. Steven Libutti

Overall Sentiment: 0

Relevance: 0.230182

Antonija Kreso

Overall Sentiment: 0

Relevance: 0.228434

Eloxatin

Overall Sentiment: 0.0622748

Relevance: 0.218384

Catherine O'Brien

Overall Sentiment: -0.132517

Relevance: 0.20343

Key:

  • Aggregate Sentiment is meant to be an indicator of an individual's overall sentiment.
  • The Mean is meant to be an indicator of an individual's average comment sentiment.
  • The Standard Deviation, when there are enough quotes, will indicate an individual's consistency of sentiment (i.e. a Standard Deviation of 0 would mean they were very consistent in their sentiment and 1 would mean they were very inconsistent).

Note that quote stats are likely to be meaningless beyond the aggregate score due to the tiny sample size. However, they are always provided just in case you find something useful there.

Additional Info:

HealthCondition: tumor

Overall Sentiment: -0.0354645

Relevance: 0.816425

HealthCondition: cancer

Overall Sentiment: -0.0568624

Relevance: 0.815498

Disambiguation: FieldOfStudy | DiseaseOrMedicalCondition | CauseOfDeath | DiseaseCause | MedicalSpecialty | RiskFactor | DiseaseReferences:

HealthCondition: colorectal cancer

Overall Sentiment: 0.0114271

Relevance: 0.452862

HealthCondition: tumors

Overall Sentiment: 0.0128822

Relevance: 0.390586

FieldTerminology: DNA

Overall Sentiment: -0.0717737

Relevance: 0.394791

Organization: Princess Margaret Cancer Centre

Overall Sentiment: -0.14761

Relevance: 0.315978

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