Perfection Is Skin Deep: Everyone Has Flawed Genes
When researchers considered the genetic sequences of 179 individuals, they discovered far more defects in the patterns of As, Ts, Gs, and Cs than they expected. When researchers considered the genetic sequences of 179 individuals, they discovered far more defects in the patterns of As, Ts, Gs, and Cs than they expected. Most of us know that no one 's perfect. However now scientists have reported that fact on a hereditary level. Researchers discovered that normal, healthy people are walking around with a surprisingly large number of mutations in their genes. It's been well known that everyone has flaws in their DNA, though, for the a lot of part, the defects are benign. It's been less clear, nevertheless, just how many errors are prowling in somebody 's genes.
People:
Chris Tyler-Smith
Overall Sentiment: 0.0258528
Relevance: 0.748465
| Sentiment | Quote |
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| 0.0348426 | "It's such an interesting question that people had been trying to make estimates from indirect approaches for a long time," says Chris Tyler-Smith ... |
| 0.0599954 | "It's such an interesting question that people had been trying to make estimates from indirect approaches for a long time," says Chris Tyler-Smith of the Wellcome Trust Sanger Institute in Cambridge, England. "There were estimates that ranged from just a handful up to 100 or more serious disease-associated mutations." |
| -0.376199 | "We found quite amazingly large numbers of deleterious and known disease-causing mutations," Tyler-Smith says. ... |
| 0 | "It could be that in some cases there's another copy of that gene or a similar gene that takes over," Tyler-Smith says. ... |
| 0.110335 | "It's a bit surprising that people should be walking around apparently healthy yet we're seeing known disease-causing mutations in their genomes," he says. ... |
| -0.104297 | "It's a bit surprising that people should be walking around apparently healthy yet we're seeing known disease-causing mutations in their genomes," he says. "But the answer was that these tended to be for mild and very often late-onset conditions. Things like heart disease, an increased risk of developing cancer." |
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James Evans
Overall Sentiment: 0.0740002
Relevance: 0.383892
Green
Overall Sentiment: -0.0977248
Relevance: 0.366056
| Sentiment | Quote |
|---|---|
| 0.30115 | "The critical take-home medicine here — one that needs to be reinforced over and over — is that as we enter the age of genomic medicine, simply having a mutation in a disease gene does not mean you have the disease or will get the disease," Green says. ... |
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Additional Info:
Organization: Wellcome Trust Sanger Institute
Overall Sentiment: 0
Relevance: 0.33785
Organization: University of North Carolina
Overall Sentiment: 0.144133
Relevance: 0.316011
Disambiguation: SportsTeam | FootballTeam | CollegeUniversity | UniversityReferences:
PrintMedia: American Journal of Human Genetics
Overall Sentiment: 0
Relevance: 0.368269
HealthCondition: heart disease
Overall Sentiment: -0.271977
Relevance: 0.90031
Disambiguation: DiseaseOrMedicalCondition | CauseOfDeath | RiskFactor | Disease | OrganizationSectorReferences:
FieldTerminology: DNA
Overall Sentiment: -0.0218382
Relevance: 0.527689
FieldTerminology: Genome Sequencing
Overall Sentiment: -0.114998
Relevance: 0.334154
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Source Site: npr.org
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Perfection Is Skin Deep: Everyone Has Flawed Genes
Provided Desc:
Researchers found a surprising number of mutations, including several associated with disease, in the genes of normal healthy people. Their study raises questions about whether widespread genetic sequencing could end up scaring people for no good reason.
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